Platelet Membrane Glycoproteins: A Historical Review
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چکیده
منابع مشابه
Platelet membrane glycoproteins: a historical review.
The search for the components of the platelet surface that mediate platelet adhesion and platelet aggregation began for earnest in the late 1960s when electron microscopy demonstrated the presence of a carbohydrate-rich, negatively charged outer coat that was called the "glycocalyx." Progressively, electrophoretic procedures were developed that identified the major membrane glycoproteins (GP) t...
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labeled membrane proteins by density gradient ultracentrifugation using 1 O%-40% sucrose gradients containing the nonionic detergent. Studies were performed using soluble proteins derived from membranes isolated in the presence or absence of EDTA. Analysis of gradient fractions by SDS-polyacrylamide gel electrophoresis showed that in the absence of divalent cation chelation. GP lIb and lIla pen...
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ژورنال
عنوان ژورنال: Seminars in Thrombosis and Hemostasis
سال: 2014
ISSN: 0094-6176,1098-9064
DOI: 10.1055/s-0034-1383826